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KMID : 1145720200080010013
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Korean Herbal Medicine Informatics
2020 Volume.8 No. 1 p.13 ~ p.24
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Protective effect of Byeol-Gab (Pelodiscis Carapax) extract in radiation-induced testicular injury
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Seo Yun-Soo
Lee A-Young
Song Jun-Ho
Moon Byeong-Cheol
Park Gun-Hyuk
Lim Hye-Sun
Kim Joong-Sun
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Abstract
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We evaluated the effect of Byeol-Gab Extract (BGE) on testicular injury in the mouse after radiation exposure. BGE (50 mg/kg) was administrated to male C57BL/6 mice by P.O for ten days before radiation exposure, and histological parameters were assessed at 6 h and 35 days post 5 Gy irradiation. The BGE attenuated radiation-induced apoptosis in germ cells after 6 h after irradiation. BGE protected testicular morphological changes, such as changes in seminiferous epithelial height after radiation exposure. BGE treatment significantly increased testis weight compared with irradiation controls at 35 days. The present study suggests that BGE attenuates radiation-induced testicular injury via an anti-apoptotic effect and recovery of spermatogenesis.
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KEYWORD
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Byeol-Gab (Biejia, Pelodiscis Carapax), Testis, Radiation, Apoptosis, We evaluated the effect of Byeol-Gab Extract (BGE) on testicular injury in the mouse after radiation exposure. BGE (50 mg/kg) was administrated to male C57BL/6 mice by P.O for ten days before radiation exposure, and histological parameters were assessed at 6 h and 35 days post 5 Gy irradiation. The BGE attenuated radiation-induced apoptosis in germ cells after 6 h after irradiation. BGE protected testicular morphological changes, such as changes in seminiferous epithelial height after radiation exposure. BGE treatment significantly increased testis weight compared with irradiation controls at 35 days. The present study suggests that BGE attenuates radiation-induced testicular injury via an anti-apoptotic effect and recovery of spermatogenesis. Mice
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